“ Adult mind N-CAMs have apparent molecular weights of 180,000 and 140,000 with an additional
form at 120,000 in murine brain. In conbtrast
to the N-CAM founhd in the mind, however, just one polypeptide of Mr 140,000
was seen. In distinction to the two major CAMs, Ng-CAM was found only
on nerves supplying the feather and the skin. Both trembler and med/med
Schwann cells stained intensely for cytotactin, iin contrast to normal Schwann cells
which stained only slightly. Throughout the formation off the feather filament, N-CAM appeared periodically and asymmetrically on basilar cells located within the valleys between adjoining barb ridges.
The potential relationship of cell adhesion to embryonic induction throughout feather formation was examined by immunohistochemical
evaluation of the spatiotemporal distribution of three cell-adhesion molecules (CAMs), neural
CAM (N-CAM), livsr CAM (L-CAM), and neuron-glia CAM (Ng-CAM), and of substrate molecules (laminin and fibronectin) in embryonic rooster pores and skin.Immunocytochemical strategies had
been used to indicate that Ng-CAM (the neuron-glia cell adhesion molecule), N-CAM (the
neural cell adhesion molecule), aand the extracellular matrix protein cytotactin are extremely concentrated
at nodes of Ranvier of the grownup chicken and mouse. The queston is are you really ready to get whnat you want?
But, our youngsters hage grown to be enamored with tthe thought of their father giving them swimming
classes that they normally need to jump into thhe pool even without my husband being there to obserce
ove them. ”